Tabla HTML con desplazamiento horizontal (primera columna fija)

Solución:

Qué tal si:

table {
  table-layout: fixed; 
  width: 100%;
  *margin-left: -100px; /*ie7*/
}
td, th {
  vertical-align: top;
  border-top: 1px solid #ccc;
  padding: 10px;
  width: 100px;
}
.fix {
  position: absolute;
  *position: relative; /*ie7*/
  margin-left: -100px;
  width: 100px;
}
.outer {
  position: relative;
}
.inner {
  overflow-x: scroll;
  overflow-y: visible;
  width: 400px; 
  margin-left: 100px;
}

<div class="outer">
  <div class="inner">
    <table>
      <tr>
        <th class=fix></th>
        <th>Col 1</th>
        <th>Col 2</th>
        <th>Col 3</th>
        <th>Col 4</th>
        <th class="fix">Col 5</th>
      </tr>
      <tr>
        <th class=fix>Header A</th>
        <td>col 1 - A</td>
        <td>col 2 - A (WITH LONGER CONTENT)</td>
        <td>col 3 - A</td>
        <td>col 4 - A</td>
        <td class=fix>col 5 - A</td>
      </tr>
      <tr>
        <th class=fix>Header B</th>
        <td>col 1 - B</td>
        <td>col 2 - B</td>
        <td>col 3 - B</td>
        <td>col 4 - B</td>
        <td class=fix>col 5 - B</td>
      </tr>
      <tr>
        <th class=fix>Header C</th>
        <td>col 1 - C</td>
        <td>col 2 - C</td>
        <td>col 3 - C</td>
        <td>col 4 - C</td>
        <td class=fix>col 5 - C</td>
      </tr>
    </table>
  </div>
</div>

Puede probarlo en este jsbin: http://jsbin.com/uxecel/4/edit

Tengo una mesa similar con este estilo:

<table style="width:100%; table-layout:fixed">
    <tr>
        <td style="width: 150px">Hello, World!</td>
        <td>
            <div>
                <pre style="margin:0; overflow:scroll">My preformatted content</pre>
            </div>
        </td>
    </tr>
</table>

Basado en el enfoque de skube, encontré que el conjunto mínimo de CSS que necesitaba era:

.horizontal-scroll-except-first-column {
  width: 100%;
  overflow: auto;
}

.horizontal-scroll-except-first-column > table {
  margin-left: 8em;
}

.horizontal-scroll-except-first-column > table > * > tr > th:first-child,
.horizontal-scroll-except-first-column > table > * > tr > td:first-child {
  position: absolute;
  width: 8em;
  margin-left: -8em;
  background: #ccc;
}

.horizontal-scroll-except-first-column > table > * > tr > th,
.horizontal-scroll-except-first-column > table > * > tr > td {
  /* Without this, if a cell wraps onto two lines, the first column
   * will look bad, and may need padding. */
  white-space: nowrap;
}

<div class="horizontal-scroll-except-first-column">
  <table>
    <tbody>
      <tr>
        <td>FIXED</td> <td>22222</td> <td>33333</td> <td>44444</td> <td>55555</td> <td>66666</td> <td>77777</td> <td>88888</td> <td>99999</td> <td>AAAAA</td> <td>BBBBB</td> <td>CCCCC</td> <td>DDDDD</td> <td>EEEEE</td> <td>FFFFF</td>
      </tr>
    </tbody>
  </table>
</div>

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